Structure of PDB 6px9 Chain B

Receptor sequence
>6px9B (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTT
TFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI
IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQTRYIPDEADFL
LGMATVWYIQSLCQSLRERSPRGDDILTILTEVNYEVSNQMPQPTFTLRK
KLVFPSD
3D structure
PDB6px9 Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity.
ChainB
Resolution2.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.61: caspase-8.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 63R B R260 G262 L265 D266 Q358 C360 V406 W420 R38 G40 L43 D44 Q136 C138 V156 W157
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6px9, PDBe:6px9, PDBj:6px9
PDBsum6px9
PubMed31927936
UniProtQ14790|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)

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