Structure of PDB 6puz Chain B

Receptor sequence
>6puzB (length=240) Species: 11698,273057 [Search protein sequence]
DGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQSPGIWQLD
CTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVH
TDNGSNFTSTTVKAACWWAGIKQEFVIESMNKELKKIIGQVRDQAEHLKT
AVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFR
VYYRWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRD
3D structure
PDB6puz Structural basis for strand-transfer inhibitor binding to HIV intasomes.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H12 C40 H10 C38
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004521 RNA endonuclease activity
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:6puz, PDBe:6puz, PDBj:6puz
PDBsum6puz
PubMed32001521
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol);
P39476|DN7D_SACS2 DNA-binding protein 7d (Gene Name=sso7d)

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