Structure of PDB 6pm9 Chain B

Receptor sequence
>6pm9B (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
RFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWR
EMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKL
DQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGE
PETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKE
IPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLK
GVLTNPNCEFEANYVAIHTLATWYKSNMNGVRDVLYSPQMALKLALTEWL
QEFGVPHQY
3D structure
PDB6pm9 Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
ChainB
Resolution2.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OQ1 B G67 Y69 K98 D174 D175 Y219 T250 V254 W278 N280 D285 G9 Y11 K40 D116 D117 Y161 T192 V196 W220 N222 D227 BindingDB: Ki=5.70nM,EC50=53nM,IC50=7.9nM
External links
PDB RCSB:6pm9, PDBe:6pm9, PDBj:6pm9
PDBsum6pm9
PubMed31487175
UniProtO60502|OGA_HUMAN Protein O-GlcNAcase (Gene Name=OGA)

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