Structure of PDB 6pkx Chain B

Receptor sequence
>6pkxB (length=1218) Species: 7955 (Danio rerio) [Search protein sequence]
LASWIKENIKKKVRETPTDAFGDISFKTGKYVRVSSDTSCENLYQLMTEQ
WKLRSPNLLISVTGKNFYIKTHLKDKFRRGLIKVAQTTGAWILTGGTHAG
VMKHVGMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLIHPEGRFPAY
YSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEIELRARLEKLISKLS
VTIPVVCVVLDGGPGTLNTIYNSMLNHTPCVVLEGSGRLADVIAHVASVP
VSKVTMALINRLLKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVFR
IDEDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELAVAWNRVDIAES
EIFTEESQWTSSDLHPAMFSALVGDKPEFVRLLLENGVCVREFLEREETL
CELYSHLPSCFFLRKLAKRVQCLSHVSEEVRHLLGSFTQPLYIASRTVWD
PGRDLFLWAVVQNNRELAEIGWEQCRDCIAAALAASKILRKLAQESGEDD
SEEATEMLELANHYEKQAIGVFSECHSWDAQRAQKLLIRISPSWGRSTCL
WLALEAHDKSFIAHSGVQALLTQIWCGELSVDNPHWKVLLCMIFFPLIYT
GFLTFRRDEDIQRQAERTEQQKCSSRLMSFLKSPQVKFYWNIASYFGFLW
LFAVVLMIDFQTSPSWRELLLYVWLTSLVCEEIRQLYHDGFRRKAKMYIK
DLWNILDVLSIVLFIAGLICRLQASDTVFYIGKVILCIDFIIFCLRLMAI
FSISRTLGPKIIIVRRMMLDLFFFMFLLSIWVVAYGVAKQGILIENEERL
NWIIRGAVYEPYITIFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNA
DNTPVFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQEVQDNTDTIWK
FQRYELIKEYHSRPALPPPFILLSHLILFIRGRHKNFRQELEQTEEEELL
SWEAYMKDNYLASTRQDESQSVEHRIHDTAEKVGAMSELLEREQEMVAAA
AAAAAAAAAAAAAAAAAAAEAPHMFARQLQYPDSTVRRFPVPEEKVSWEV
NFSPYQPPVYNQQDKHRNPGGRTGIRGKGALNTLGPNHILHPIFTRWRDA
EHKVLEFLAVWEDAEKRWALLGGPAQPDLAQVLERILGKKLKTLLKAGEE
VYKGYVDDSRNTDNAWVETSIITLHTPLMADLNHMVESSQPLQWREVSSD
ACRCSYQREALRQIAHHH
3D structure
PDB6pkx Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
ChainB
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B Q860 N883 Q685 N704
BS02 AR6 B K154 T186 Y271 G308 G309 P310 G311 K65 T97 Y182 G212 G213 P214 G215
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
GO:0072570 ADP-D-ribose binding
GO:0072571 mono-ADP-D-ribose binding
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0019722 calcium-mediated signaling
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pkx, PDBe:6pkx, PDBj:6pkx
PDBsum6pkx
PubMed31431622
UniProtA0A0R4IMY7|TRPM2_DANRE Transient receptor potential cation channel subfamily M member 2 (Gene Name=trpm2)

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