Structure of PDB 6pit Chain B

Receptor sequence
>6pitB (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLTADQMVSALLDAEPPILYSESMMGLLTNLADRELVHMINWAKRVPGF
VDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKC
VEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTDHIHRVL
DKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMK
CKNVVPLSDLLLEMLDAH
3D structure
PDB6pit Versatile Peptide Macrocyclization with Diels-Alder Cycloadditions.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 L372 V376 E542 I41 L55 V59 E213
BS02 EST B L346 E353 L387 M421 H524 L525 L29 E36 L70 M104 H195 L196 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:6pit, PDBe:6pit, PDBj:6pit
PDBsum6pit
PubMed31523967
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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