Structure of PDB 6phz Chain B

Receptor sequence
>6phzB (length=344) Species: 1658765 (Marinobacter subterrani) [Search protein sequence]
GSMKTVFSPLHSRRHVKTELDGGLLIEPHEKPSRAETILARVKDQALGEI
LEPEEFGLGPVKRVHTADYVSFLETCWDEWVAAGKRGEAIPTFWVGRGMR
ARLPKDIDGRLGYYSLGADTSISDGTWEAARASANVALTAQKLVAEGERA
AFALCRPPGHHAHADVFGGYCFFNNAAIAAQAFRDQGYGKVAVLDVDFHH
GNGTQAIFYDRSDVLTISLHGDPDLVFPHFLGFEDETGEGDGEAYNLNIV
FPPDTPFSIWSQGLEKACERIRTFAPDALVVALGVDTFEEDPISFFKLTS
GDYLKLGKRLEQLGLPTVFTMEGGYDVDAIGVNAVNVMQGFEGK
3D structure
PDB6phz Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D195 H197 D284 D197 H199 D286
BS02 MG B D104 D106 D106 D108
BS03 FKS B E17 L18 D19 D117 P156 H158 H159 G167 Y168 D195 H197 F225 E320 G321 Y323 E19 L20 D21 D119 P158 H160 H161 G169 Y170 D197 H199 F227 E322 G323 Y325 MOAD: ic50=350uM
PDBbind-CN: -logKd/Ki=3.46,IC50=350uM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006338 chromatin remodeling

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Molecular Function
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Biological Process
External links
PDB RCSB:6phz, PDBe:6phz, PDBj:6phz
PDBsum6phz
PubMed31436969
UniProtA0A0J7JFD7

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