Structure of PDB 6pfo Chain B

Receptor sequence

>6pfoB (length=474) Species: 562 (Escherichia coli)

MAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFP
QVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVR
YNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALM
FNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDL
IKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLP
TFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKP
LGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVI
NAASGRQTVDEALKDAQTNAAAEFPFLYVVGRKKMMDAQYKCYDRMQQLP
AYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCD
EKGVWFKHPENNRTWSNYTMCNAF

3D structure

• PDB: 6pfo Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics.
• Chain: B
• Resolution: 1.78 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	Q-263 Y-236 N-235 D-158 I-157 P-1 Q0 F37 L40 Y41 D77 W79 P100 D101 H121 E123 N124 W128 S129 N135 F137	Q74 Y101 N102 D179 I180 P336 Q337 F374 L377 Y378 D414 W416 P437 D438 H458 E460 N461 W465 S466 N472 F474
BS02	GLC	B	D-321 K-320 E-224 W-105	D16 K17 E113 W232
BS03	GLC	B	W-273 D-270 R-269 E-182 P-181 Y-180 W5	W64 D67 R68 E155 P156 Y157 W342

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0015144 carbohydrate transmembrane transporter activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0008643 carbohydrate transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6pfo, PDBe:6pfo, PDBj:6pfo
• PDBsum: 6pfo
• PubMed: 32035902
• UniProt: P30988|CALCR_HUMAN Calcitonin receptor (Gene Name=CALCR)