Structure of PDB 6pet Chain B

Receptor sequence
>6petB (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTSMMGLLTNLADRELVHMINWA
KRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTF
TLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHI
RHMSNKGMEHLYSMKPSYDLLLEML
3D structure
PDB6pet Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
ChainB
Resolution2.203 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ODY B L346 T347 L349 A350 D351 E353 L391 F404 M421 H524 L525 L35 T36 L38 A39 D40 E42 L80 F93 M110 H210 L211 BindingDB: IC50=0.050000nM
External links
PDB RCSB:6pet, PDBe:6pet, PDBj:6pet
PDBsum6pet
PubMed31311734
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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