Structure of PDB 6pdt Chain B

Receptor sequence
>6pdtB (length=500) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MSFDDLHKATERAVIQAVDQICDDFEVTPEKLDELTAYFIEQMEKGLAPP
KEGHTLASDKGLPMIPAFVTGSPNGTERGVLLAADLGGTNFRICSVNLHG
DHTFSMEQMKSKIPDDLLDDENVTSDDLFGFLARRTLAFMKKYHPDELAK
GKDAKPMKLGFTFSYPVDQTSLNSGTLIRWTKGFRIADTVGKDVVQLYQE
QLSAQGMPMIKVVALTNDTVGTYLSHCYTSDNTDSMTSGEISEPVIGCIF
GTGTNGCYMEEINKITKLPQELRDKLIKEGKTHMIINVEWGSFDNELKHL
PTTKYDVVIDQKLSTNPGFHLFEKRVSGMFLGEVLRNILVDLHSQGLLLQ
QYRSKEQLPRHLTTPFQLSSEVLSHIEIDDSTGLRETELSLLQSLRLPTT
PTERVQIQKLVRAISRRSAYLAAVPLAAILIKTNALNKRYHGEVEIGCDG
SVVEYYPGFRSMLRHALALSPLGAEGERKVHLKIAKDGSGVGAALCALVA
3D structure
PDB6pdt Polymerization in the actin ATPase clan regulates hexokinase activity in yeast.
ChainB
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.2: glucokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC B P166 T181 K182 N217 N255 E289 E323 P166 T181 K182 N217 N255 E289 E323
BS02 ATP B G87 G88 T89 R92 K182 G251 T252 S370 E371 S374 G450 S451 G87 G88 T89 R92 K182 G251 T252 S370 E371 S374 G450 S451
Gene Ontology
Molecular Function
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005536 D-glucose binding
GO:0008865 fructokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0001678 intracellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006013 mannose metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0019318 hexose metabolic process
GO:0046323 D-glucose import
GO:0046835 carbohydrate phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pdt, PDBe:6pdt, PDBj:6pdt
PDBsum6pdt
PubMed32108112
UniProtP17709|HXKG_YEAST Glucokinase-1 (Gene Name=GLK1)

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