Structure of PDB 6p6q Chain B

Receptor sequence
>6p6qB (length=196) Species: 11104 (Hepatitis C virus (isolate 1)) [Search protein sequence]
HMAKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEV
QIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLV
GWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSTGSLLSPRPLS
YLKGSSGGPLLCPAGHAVGIFRAAVSTRGVAKAVQFIPVESLETTM
3D structure
PDB6p6q Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SUE B Q1041 F1043 H1057 V1078 D1081 L1135 K1136 G1137 S1139 F1154 A1156 A1157 Q1168 Q58 F60 H74 V95 D98 L152 K153 G154 S156 F171 A173 A174 Q185
BS02 ZN B C1145 H1149 C162 H166
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6p6q, PDBe:6p6q, PDBj:6p6q
PDBsum6p6q
PubMed
UniProtP26664|POLG_HCV1 Genome polyprotein

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