Structure of PDB 6p3a Chain B

Receptor sequence
>6p3aB (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDL
ETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVC
YQTLTEYDEHLTQLEKDICTAKEAAL
3D structure
PDB6p3a Crystal Structure Analysis of TAF1 Bromodomain
ChainB
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NQP B W1547 P1548 F1549 V1553 Y1561 Y1603 W26 P27 F28 V32 Y40 Y82 BindingDB: IC50=82nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017025 TBP-class protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0005669 transcription factor TFIID complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6p3a, PDBe:6p3a, PDBj:6p3a
PDBsum6p3a
PubMed
UniProtP21675|TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (Gene Name=TAF1)

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