Structure of PDB 6p2j Chain B

Receptor sequence
>6p2jB (length=408) Species: 9606 (Homo sapiens) [Search protein sequence]
QGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRL
VLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPL
IRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKA
HSFVRENVPRVLNSSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWG
YVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSIL
PGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWN
VVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFF
YPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQE
WYARQHCP
3D structure
PDB6p2j Structural basis for catalysis and substrate specificity of human ACAT1.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.26: sterol O-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3VV B W407 S414 N415 Y417 W420 N421 H425 Y429 Y433 K445 M449 F453 S456 H460 F476 F479 W286 S293 N294 Y296 W299 N300 H304 Y308 Y312 K324 M328 F332 S335 H339 F355 F358
Gene Ontology
Molecular Function
GO:0000062 fatty-acyl-CoA binding
GO:0004772 sterol O-acyltransferase activity
GO:0005515 protein binding
GO:0008374 O-acyltransferase activity
GO:0015485 cholesterol binding
GO:0016746 acyltransferase activity
GO:0034736 cholesterol O-acyltransferase activity
Biological Process
GO:0008203 cholesterol metabolic process
GO:0010742 macrophage derived foam cell differentiation
GO:0010878 cholesterol storage
GO:0033344 cholesterol efflux
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034383 low-density lipoprotein particle clearance
GO:0042632 cholesterol homeostasis
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6p2j, PDBe:6p2j, PDBj:6p2j
PDBsum6p2j
PubMed32433614
UniProtP35610|SOAT1_HUMAN Sterol O-acyltransferase 1 (Gene Name=SOAT1)

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