Structure of PDB 6p25 Chain B

Receptor sequence
>6p25B (length=690) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence]
SSLLRLESVVMPVIFTALALFTRMYKIGINNHVVWDEAHFGKFGSYYLRH
EFYHDVHPPLGKMLVGLSGYLAGYNGSWDFPSGEIYPDYLDYVKMRLFNA
SFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSML
LFFTVASFFSFVMFHNQRSKPFSRKWWKWLLITGISLGCTISVKMVGLFI
ITMVGIYTVIDLWTFLADKSMSWKTYINHWLARIFGLIIVPFCIFLLCFK
IHFDLLSHSGTGDANMPSLFQARLVGSDVGQGPRDIALGSSVVSIKNQAL
GGSLLHSHIQTYPDGSNQQQVTCYGYKDANNEWFFNRERGLPSWSENETD
IEYLKPGTSYRLVHKSTGRNLHTHPVAAPVSKTQWEVSGYGDNVVGDNKD
NWVIEIMDQRGDEDPEKLHTLTTSFRIKNLEMGCYLAQTGNSLPEWGFRQ
QEVVCMKNPFKRDKRTWWNIETHENDFQYPKTNFLKDFIHLNLAMMATNN
ALVPDPDKFDYLASSAWQWPTLNVGLRLCGWGDDNPKYFLLGTPASTWAS
SVAVLAFMATVVILLIRWQRQYVDLRNPSNWNVFLMGGFYPLLAWGLHYM
PFVIMSRVTYVHHYLPALYFALIILAYCFDAGLQKWSRSKCGRIMRFVLY
AGFMALVIGCFWYFSPISFGMEGPSSNFRYLNWFSTWDIA
3D structure
PDB6p25 Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex.
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.109: dolichyl-phosphate-mannose--protein mannosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B W91 D92 H95 L592 Y674 W35 D36 H39 L528 Y610
BS02 CPL B I627 I630 R634 Y636 I563 I566 R570 Y572
BS03 CPL B V616 A620 T624 L628 D638 Y691 K699 V552 A556 T560 L564 D574 Y627 K635
Gene Ontology
Molecular Function
GO:0000030 mannosyltransferase activity
GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0009272 fungal-type cell wall biogenesis
GO:0032527 protein exit from endoplasmic reticulum
GO:0035269 protein O-linked mannosylation
GO:0036503 ERAD pathway
GO:1900101 regulation of endoplasmic reticulum unfolded protein response
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0097582 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex
GO:0097584 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6p25, PDBe:6p25, PDBj:6p25
PDBsum6p25
PubMed31285605
UniProtP31382|PMT2_YEAST Dolichyl-phosphate-mannose--protein mannosyltransferase 2 (Gene Name=PMT2)

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