Structure of PDB 6p13 Chain B

Receptor sequence
>6p13B (length=280) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
GVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELF
TGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGE
KLVRALFAVARHMQPSIIFIDEVDSLLSRRLKTEFLVEFDGLPDRIVVLA
ATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEAL
RRLAKITDGYSGSDLAALAKDAALEPIRELNVEQVKCLDISAMRAITEQD
FHSSLKRIRRSVAPQSLNSYEKWSQDYGDI
3D structure
PDB6p13 Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NKY B D484 I485 A486 Q488 N527 L531 S649 L650 P651 T655 L659 G688 S689 D25 I26 A27 Q29 N68 L72 S173 L174 P175 T179 L183 G212 S213 MOAD: ic50=0.22uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6p13, PDBe:6p13, PDBj:6p13
PDBsum6p13
PubMed31257183
UniProtQ8I0P1|SPAST_DROME Spastin (Gene Name=spas)

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