Structure of PDB 6ozr Chain B

Receptor sequence

>6ozrB (length=248) Species: 10090 (Mus musculus)

AERPPEETLSLWKGEQARLKARVVDRDTEAWQRDPSFSGLQKVGGVDVSF
VKGDSVRACASLVVLSYPELKVVYEDSRMVGLKAPYVSGFLAFREVPFLV
ELVQRLQEKEPDLMPQVVLVDGNGVLHQRGFGVACHLGVLTELPCIGVAK
KLLQVDGLENNALHKEKIVLLQAGGDTFPLIGSSGTVLGMALRSHDHSTK
PLYVSVGHRISLEVAVRLTHHCCRFRIPEPIRQADIRSREYIRRTLGQ

3D structure

• PDB: 6ozr Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.
• Chain: B
• Resolution: 2.15 Å

Enzymatic activity

• Enzyme Commision number: 3.1.26.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	H200 H202 S203 T204 K205 F230 R231 R237 R244	H195 H197 S198 T199 K200 F225 R226 R232 R239
BS02	rna	B	V53 S54 F55 K57 Y91 S93 G94 L96 N128 H132 G137 V138 A154 K155 K156 L158 Q159 R244	V48 S49 F50 K52 Y86 S88 G89 L91 N123 H127 G132 V133 A149 K150 K151 L153 Q154 R239
BS03	MG	B	D52 D126 D240	D47 D121 D235

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6ozr, PDBe:6ozr, PDBj:6ozr
• PDBsum: 6ozr
• PubMed: 31444105
• UniProt: Q8C9A2|ENDOV_MOUSE Endonuclease V (Gene Name=Endov)