Structure of PDB 6ony Chain B

Receptor sequence
>6onyB (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
RVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDM
GTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIF
LQKVASMPQE
3D structure
PDB6ony Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
ChainB
Resolution1.98 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HWV B W97 P98 Q101 V103 L108 N156 I162 W24 P25 Q28 V30 L35 N83 I89 BindingDB: Ki=4.6nM
External links
PDB RCSB:6ony, PDBe:6ony, PDBj:6ony
PDBsum6ony
PubMed31969702
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

[Back to BioLiP]