Structure of PDB 6oix Chain B

Receptor sequence
>6oixB (length=471) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
QIDFRKKINWHRRYRSPQGVKTEHEILRIFESDRGRIINSPAIRRLQQKT
QVFPLEAAVRTRLTHSMEVQQVGRYIAKEILSRLKELKLLEAYGLDELTG
PFESIVEMSCLMHDIGNPPFGHFGEAAINDWFRQRLHPEDAESQPLTDDR
CSVAALRLLNELRRKIRQDLCHFEGNAQGIRLVHTLMRMNLTWAQVGGIL
KYTRPAWWRGETPETHHYLMKKPGYYLSEEAYIARLRKELNLALYSRFPL
TWIMEAADDISYCVADLEDAVEKRIFTVEQLYHHLHFSLVVENAWEKSST
EDQFFMYLRVNTLNKLVPYAAQRFIDNLPAIFAGTFNHALLESDLLKLYK
NVAVKHVFSHPDVERLELQGYRVISGLLEIYRPLLSLSLSDFTELVEKER
VKRFPIESRLFHKLSTRHRLAYVEAVSKLPSDSPEFPLWEYYYRCRLLQD
YISGMTDLYAWDEYRRLMAVE
3D structure
PDB6oix The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity.
ChainB
Resolution3.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 H117 D118 D268 R442
Catalytic site (residue number reindexed from 1) H65 H113 D114 D258 R409
Enzyme Commision number 3.1.5.1: dGTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B V54 H117 H126 K231 Y272 D276 F391 V52 H113 H122 K221 Y262 D266 F358
BS02 MN B H69 H117 D118 D268 H65 H113 D114 D258
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003697 single-stranded DNA binding
GO:0003924 GTPase activity
GO:0008832 dGTPase activity
GO:0016787 hydrolase activity
GO:0016793 triphosphoric monoester hydrolase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0050897 cobalt ion binding
Biological Process
GO:0006203 dGTP catabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0043099 pyrimidine deoxyribonucleoside salvage

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Molecular Function
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Biological Process
External links
PDB RCSB:6oix, PDBe:6oix, PDBj:6oix
PDBsum6oix
PubMed31019074
UniProtP15723|DGTP_ECOLI Deoxyguanosinetriphosphate triphosphohydrolase (Gene Name=dgt)

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