Structure of PDB 6ohm Chain B

Receptor sequence
>6ohmB (length=584) Species: 9606 (Homo sapiens) [Search protein sequence]
RDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDW
WLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSG
YSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGR
WDDLHYRLTDLGPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRET
TPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPK
TLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFF
ISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTG
GGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGEL
GGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDT
ETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQ
LWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARS
ELTQVQGHLVHFPLKFLEDESLLPPGMIPLEVWT
3D structure
PDB6ohm Human PLD structures enable drug design and characterization of isoenzyme selectivity.
ChainB
Resolution1.895 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.4: phospholipase D.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WO4 B H442 K444 Q642 H756 K758 N773 H128 K130 Q298 H412 K414 N429
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
Biological Process
GO:0006654 phosphatidic acid biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6ohm, PDBe:6ohm, PDBj:6ohm
PDBsum6ohm
PubMed32042197
UniProtO14939|PLD2_HUMAN Phospholipase D2 (Gene Name=PLD2)

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