Structure of PDB 6ofb Chain B

Receptor sequence
>6ofbB (length=696) Species: 9606 (Homo sapiens) [Search protein sequence]
RKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYG
CWDHYYESDTLLHSFQVLAALLESPVTQDIICDVGMPVMHRNVRYNCRVI
FLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTK
QETVPFGDAVLVTWDTCIGSEICEELWTPHSPHIDMGLDGVEIITNASGS
HHVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNG
SVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVK
VDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGF
LLPLSGGVDSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTP
QDPRDLCGRILTTCYMASKNSSQETCTRARELAQQIGSHHISLNIDPAVK
AVMGIFSLVTGKSPLFAAHGGSSRENLALQNVQARIRMVLAYLFAQLSLW
SRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIGGISKTDLRAFVQ
FCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSVYG
KLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTT
LTPAYHAENYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAE
3D structure
PDB6ofb Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+synthetases.
ChainB
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.5.1: NAD(+) synthase (glutamine-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DND B Q349 L510 D535 Q347 L508 D533
BS02 DND B L479 N483 R487 H648 K649 L477 N481 R485 H646 K647
BS03 AMP B P355 L356 S357 M418 R489 A573 P353 L354 S355 M416 R487 A571
BS04 POP B S357 G359 D361 S362 S355 G357 D359 S360
BS05 MG B V360 D361 V358 D359
Gene Ontology
Molecular Function
GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity
GO:0004359 glutaminase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0009435 NAD biosynthetic process
GO:0034627 'de novo' NAD biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ofb, PDBe:6ofb, PDBj:6ofb
PDBsum6ofb
PubMed31911602
UniProtQ6IA69|NADE_HUMAN Glutamine-dependent NAD(+) synthetase (Gene Name=NADSYN1)

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