Structure of PDB 6o8e Chain B

Receptor sequence

>6o8eB (length=590) Species: 1395 ([Bacillus] caldotenax)

GRFQLVAPYEPQGDQPQAIAKLVDGLRRGVKHQTLLGATGTGKTFTISNV
IAQVNKPTLVIAHNKTLAGQLYSELKEFFPHNAVEYFVSYYDYYQPEAYV
PQTDTYIEKDAKINDEIDKLRHSATSALFERRDVIIVASVSSIYGLGSPE
EYRELVVSLRVGMEIERNALLRRLVDIQYDRNDIDFRRGTFRVRGDVVEI
FPASRDEHSIRVEFFGDEIERIREVDALTGEVLGEREHVAIFPASHFVCR
EEKMRLAIQNIEQELEERLAELRAQGKLLEAQRLEQRTRYDLEMMREMGF
SSGIENYSRHLALRPPGSTPYTLLDYFPDDFLIIVDESHVTLPQLRGMYN
GDRARKQVLVDHGFRLPSALDNRPLTFEEFEQKINQIIYVSATPGPYELE
HSPGVVEQIIRPTGLLDPTIDVRPTKGQIDDLIGEIRERVERNERTLVTT
LTKKMAEDLTDYLKEAGIKVAYLHSEIKTLERIEIIRDLRLGKYDVLVGI
NLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNANGHVIMY
ADTITKSMEIAIQETKRRRAIQEEYNRKHGIVPRTVKKEI

3D structure

• PDB: 6o8e Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
• Chain: B
• Resolution: 2.61 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K67 S91 Y92 Y93 Y96 K111 A113 S141 S143 Y146 F249 E307 Q346 M350 T454 K455 S477 R484 I502 N503 L504 F527	K65 S89 Y90 Y91 Y94 K109 A111 S139 S141 Y144 F247 E305 Q344 M348 T452 K453 S475 R482 I500 N501 L502 F525
BS02	dna	B	Y95 Q97 P98 D112 K114 M300 P345 G349 G353 E525 G526 F527	Y93 Q95 P96 D110 K112 M298 P343 G347 G351 E523 G524 F525
BS03	ADP	B	Y11 Q14 Q17 G42 G44 K45 P414 R543	Y9 Q12 Q15 G40 G42 K43 P412 R541

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006289 nucleotide-excision repair

Cellular Component

• GO:0009380 excinuclease repair complex

External links

• PDB: RCSB:6o8e, PDBe:6o8e, PDBj:6o8e
• PDBsum: 6o8e
• PubMed: 31549070
• UniProt: P56981|UVRB_BACCA UvrABC system protein B (Gene Name=uvrB)