Structure of PDB 6o60 Chain B

Receptor sequence
>6o60B (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
KDVIIKSDAPDTLLLEKHADYIASYGDDYEYCMSEYLRMSGIYWGLTVMD
LMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLY
DSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGK
LDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLH
QVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWI
DREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKP
VNPVFCMPEEVLQRVNVQPE
3D structure
PDB6o60 GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
ChainB
Resolution2.503 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.60: protein geranylgeranyltransferase type II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D238 C240 H290 D230 C232 H282
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004659 prenyltransferase activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008318 protein prenyltransferase activity
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0007601 visual perception
GO:0018344 protein geranylgeranylation
GO:0036211 protein modification process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005968 Rab-protein geranylgeranyltransferase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6o60, PDBe:6o60, PDBj:6o60
PDBsum6o60
PubMed31209342
UniProtP53611|PGTB2_HUMAN Geranylgeranyl transferase type-2 subunit beta (Gene Name=RABGGTB)

[Back to BioLiP]