Structure of PDB 6nzg Chain B

Receptor sequence

>6nzgB (length=837) Species: 820 (Bacteroides uniformis)

QRQTQTINDSWKFLKGECTAAADSAFDDSKWTSIHLPHTWNTDAYTEKDY
YRGTGWYRRQLTLPQGWKEKQIILRLDAAGKSATIYINGKNVGEHAGGYT
ACSFNITPFLSFDTPNTLAVCVDNARQDIAPISGDFTFFGGIYRDVWLTA
VPNQHFNLTNHGSDGLFISTPQVSEEQATLSIRGEVKNDAPEKATLELTH
TIYRPDGTLLQTLKKNIQLKAGETYAFSNEATPVLKPELWTPETPRLYRV
ETTLRNRKTKTLLDQSNHYTAFRWFRFDGDEGFFLNGKPYKLRGICRHQD
QKPIGPALTDEMHRRDFLLMKEMGANFIRISHYPQDDALLEMCDKLGMLA
WEEIPIIDIVPNTPGYGDNCERNLREMIRQHYNHPSIITWGYMNEILLVT
QRKYKTEAELKPVLERTLALANRLERVLKEEDSTRISTMAFHGSNSYNET
GLSKITDIVGWNLYQGWYGGDLTGFEKFLAQQHQNHPTHPMIVSEYGAGS
DKRLHSLHPRAFDFSIEYQQKYLEHYLPVLEDTPYICGGTHWNFIDFSSA
LRDESMPRINNKGLVYADRTPKDVYHYYQAAWRKDIPVLHIASRDWTDRA
GVQQGNAPVYLPVKIYTNLSEVELFIDGISLGKQKTENYTATFEVPFSNR
NPFLFAQGNYQGKTVQDGLRINFTPIPACLDANNLKGLELAVNVGSQCFF
TSDESQLTWLPDQPYAAGSWGYIGGKEGTAQTEIQNTADGPLFQTLRNEI
EGYRFDAPQGVYEIELLFTDIFRESTFGISINGEVVEESLSPCKESGYFR
ALRKKYYITNDKEYIDIRFHSTSGTCFLNGIKLRNIY

3D structure

• PDB: 6nzg Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling.
• Chain: B
• Resolution: 2.43 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D166 H329 H363 I388 I390 E426 Y495 E526 S586 I590 K593
• Catalytic site (residue number reindexed from 1): D135 H298 H332 I357 I359 E395 Y464 E495 S555 I559 K562
• Enzyme Commision number: 3.2.1.23: beta-galactosidase.
  3.2.1.31: beta-glucuronidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	L9D	B	D166 H363 N425 Y495 E526 W573 K593	D135 H332 N394 Y464 E495 W542 K562
BS02	CA	B	D176 D341 D367	D145 D310 D336

Gene Ontology

Molecular Function

• GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds

Biological Process

• GO:0005975 carbohydrate metabolic process

External links

• PDB: RCSB:6nzg, PDBe:6nzg, PDBj:6nzg
• PDBsum: 6nzg
• PubMed: 31774274
• UniProt: A0A414F142