Structure of PDB 6nyy Chain B

Receptor sequence

>6nyyB (length=487) Species: 9606 (Homo sapiens)

VGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKI
PKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVR
DLFALARKNAPCILFIDQIDAVGRKRGNFGGQSEQENTLNQLLVEMDGFN
TTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLR
PLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQ
KHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHQAGHAVAGWYLEHADPLL
KVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRI
TTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEA
TARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMV
ELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDW

3D structure

• PDB: 6nyy Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.
• Chain: B
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 3.4.24.-
  3.6.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	M380 F381 V382 F421	M90 F91 V92 F129
BS02	peptide	B	F516 I553 Q575 G602 L603 G604 A606	F224 I261 Q283 G310 L311 G312 A314
BS03	ANP	B	D309 V310 G351 T352 G353 K354 T355 L356 Q408 I486 H490 G518	D19 V20 G61 T62 G63 K64 T65 L66 Q118 I194 H198 G226
BS04	ZN	B	H574 H578 D649	H282 H286 D357

Gene Ontology

Molecular Function

• GO:0004176 ATP-dependent peptidase activity
• GO:0004222 metalloendopeptidase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6nyy, PDBe:6nyy, PDBj:6nyy
• PDBsum: 6nyy
• PubMed: 31327635
• UniProt: Q9Y4W6|AFG32_HUMAN Mitochondrial inner membrane m-AAA protease component AFG3L2 (Gene Name=AFG3L2)