Structure of PDB 6npm Chain B

Receptor sequence
>6npmB (length=134) Species: 10377 (Human herpesvirus 4 strain B95-8) [Search protein sequence]
SNPKFENIAEGLRALLARSHVERTTDEGTWVAGVFVYGGSKTSLYNLRRG
TALAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFMVFLQTHIFAE
VLKDAIKDLVMTKPAPTCNIRVTVCSFDDGVDLP
3D structure
PDB6npm Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
ChainB
Resolution1.603 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KVD B N480 I481 G484 S516 N519 L582 K586 T590 N7 I8 G11 S43 N46 L109 K113 T117 MOAD: Ki=110uM
PDBbind-CN: -logKd/Ki=3.96,IC50=110uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006275 regulation of DNA replication
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0042025 host cell nucleus

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Cellular Component
External links
PDB RCSB:6npm, PDBe:6npm, PDBj:6npm
PDBsum6npm
PubMed30842315
UniProtP03211|EBNA1_EBVB9 Epstein-Barr nuclear antigen 1 (Gene Name=EBNA1)

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