Structure of PDB 6nkp Chain B

Receptor sequence
>6nkpB (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
PGEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSG
DQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAE
SDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTR
KGFYLAFQDIGACVALLSVRVYYKKAHHH
3D structure
PDB6nkp Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
ChainB
Resolution2.033 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B L54 M55 Q56 N57 M59 Y65 M66 C70 R103 F108 P109 F156 R159 V161 C188 V189 L29 M30 Q31 N32 M34 Y40 M41 C45 R78 F83 P84 F131 R134 V136 C163 V164
BS02 BTN B L44 T45 Y48 T132 F134 L19 T20 Y23 T107 F109
External links
PDB RCSB:6nkp, PDBe:6nkp, PDBj:6nkp
PDBsum6nkp
PubMed31015204
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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