Structure of PDB 6nk2 Chain B

Receptor sequence
>6nk2B (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
SQGPGEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNV
MSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLY
YAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGP
LTRKGFYLAFQDIGACVALLSVRVYYKKA
3D structure
PDB6nk2 Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N133 Q135 R137 N111 Q113 R115
BS02 peptide B G39 L54 M55 Q56 N57 M59 Y65 M66 C70 R103 F108 F156 R159 V161 C188 V189 G17 L32 M33 Q34 N35 M37 Y43 M44 C48 R81 F86 F134 R137 V139 C166 V167
External links
PDB RCSB:6nk2, PDBe:6nk2, PDBj:6nk2
PDBsum6nk2
PubMed31015204
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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