Structure of PDB 6nft Chain B

Receptor sequence
>6nftB (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
RQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRY
FDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLA
EHLSHFGIDMLKMQKT
3D structure
PDB6nft Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain.
ChainB
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C199 C202 C219 H232 C26 C29 C46 H59
BS02 KKG B W209 G220 R221 Y223 Y259 Y261 W36 G47 R48 Y50 Y86 Y88 BindingDB: Kd=220000nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:6nft, PDBe:6nft, PDBj:6nft
PDBsum6nft
PubMed31663737
UniProtP45974|UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (Gene Name=USP5)

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