Structure of PDB 6ncg Chain B

Receptor sequence
>6ncgB (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
PEGKVLDDMEGNQWVLGKKIGSFGLIYLAFPTNKKDARHVVKVENGPLFS
ELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFRSYRFMVMERL
GIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLL
GYKNPDQVYLADYGLSYRYCPNGTIEFTSLDAHKGVALSRRSDVEILGYC
MLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIA
QFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFS
3D structure
PDB6ncg Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitor
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KJD B I35 V59 K61 M121 L124 A185 I20 V40 K42 M97 L100 A161 BindingDB: Kd=401nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ncg, PDBe:6ncg, PDBj:6ncg
PDBsum6ncg
PubMed
UniProtQ86Y07|VRK2_HUMAN Serine/threonine-protein kinase VRK2 (Gene Name=VRK2)

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