Structure of PDB 6n7f Chain B

Receptor sequence
>6n7fB (length=450) Species: 301447 (Streptococcus pyogenes serotype M1) [Search protein sequence]
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPK
KVMWYGAQVADILGTYAKDYGFDFKEKAFDFKQLKANRQAYIDRIHASYE
RGFEQNGVDRIYDYAVFKDAHTVEIAGQLYTAPHILIATGGHPVFPDIEG
AQYGISSDGFFALDEVPKRTAVVGAGYIAVELAGVLHALGSKTDLFIRHD
RPLRSFDKTIVDVLVDEMAVNGPRLHTHAEVAKVVKNTDESLTLYLKDGQ
EVEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKGYIETDAYENTSVKGIYA
VGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVIFSHPVIG
SVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTE
KIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
3D structure
PDB6n7f 1.90 Angstrom Resolution Crystal Structure of Glutathione Reductase from Streptococcus pyogenes in Complex with FAD.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C42 C47 K50 Y177 E181 H439 E444
Catalytic site (residue number reindexed from 1) C42 C47 K50 Y177 E181 H439 E444
Enzyme Commision number 1.8.1.7: glutathione-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B I10 G11 G13 S14 A15 A33 E34 G35 K36 G40 T41 C42 G46 C47 K50 Y114 A115 T139 G140 Y177 R263 G302 D303 A309 L310 T311 I10 G11 G13 S14 A15 A33 E34 G35 K36 G40 T41 C42 G46 C47 K50 Y114 A115 T139 G140 Y177 R263 G302 D303 A309 L310 T311
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6n7f, PDBe:6n7f, PDBj:6n7f
PDBsum6n7f
PubMed
UniProtQ9A0E2

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