Structure of PDB 6n13 Chain B

Receptor sequence
>6n13B (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
NSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMS
GECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTD
VRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGC
PNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLP
EPDCRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRV
DERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRL
EWCWNCGCEWNRVCMGDHWFDV
3D structure
PDB6n13 Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
ChainB
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C253 H257 C289 C293 C110 H114 C146 C150
BS02 ZN B E370 H373 C377 E227 H230 C234
BS03 ZN B C166 C196 C201 C23 C53 C58
BS04 ZN B C238 C263 C95 C120
BS05 ZN B C337 L358 C194 L215
BS06 ZN B C418 C421 C436 C275 C278 C293
BS07 ZN B C150 C154 C212 C7 C11 C69
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6n13, PDBe:6n13, PDBj:6n13
PDBsum6n13
PubMed30446597
UniProtO60260|PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Gene Name=PRKN)

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