Structure of PDB 6mzw Chain B

Receptor sequence
>6mzwB (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
YELPEDPRWELPRDRLVLGKPLGQVVLAEAIGLDKPNRVTKVAVKMLKSD
ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
REYLQARRPQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED
NVMKIADFPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV
PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL
DRIVALTS
3D structure
PDB6mzw TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D623 R627 N628 D641
Catalytic site (residue number reindexed from 1) D139 R143 N144 D157
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TZ0 B L484 G485 A512 K514 M535 A564 L630 D641 F642 L22 G23 A43 K45 M66 A95 L146 D157 F158 BindingDB: IC50=3.6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6mzw, PDBe:6mzw, PDBj:6mzw
PDBsum6mzw
PubMed30600916
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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