Structure of PDB 6myn Chain B

Receptor sequence
>6mynB (length=328) Species: 10090 (Mus musculus) [Search protein sequence]
PVEEYLVHALQGSVSSGQAHSLASLAKTWSDNEGVLLTEKLKPVDYEYRE
EVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACA
GLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYY
LGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDG
LGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHP
WTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAM
ELRRKVGKALQEVGGLKSPWKGEYKEPR
3D structure
PDB6myn Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).
ChainB
Resolution2.744 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D517 L553
Catalytic site (residue number reindexed from 1) D170 L206
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K6Y B R410 G411 V416 A429 K431 E442 V455 I469 M471 L473 L474 L524 C535 D536 F537 R63 G64 V69 A82 K84 E95 V108 I122 M124 L126 L127 L177 C188 D189 F190
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6myn, PDBe:6myn, PDBj:6myn
PDBsum6myn
PubMed31531194
UniProtQ9WUL6|M3K14_MOUSE Mitogen-activated protein kinase kinase kinase 14 (Gene Name=Map3k14)

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