Structure of PDB 6mx0 Chain B

Receptor sequence
>6mx0B (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLSMADPNIRFLDKLPQYSNSIYELLENGQRAGTCVLEYATPL
QTLFAMSQYSQAGFSREDRLEQAKLFCQTLEDILADAPESQNNCRLIAYQ
EPADDSSFSLSQEVLRHLRQE
3D structure
PDB6mx0 Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
ChainB
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B A318 D320 A153 D155
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6mx0, PDBe:6mx0, PDBj:6mx0
PDBsum6mx0
PubMed30655953
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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