Structure of PDB 6mwe Chain B

Receptor sequence
>6mweB (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
YPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRGELEVLCKL
GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIA
NSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAK
IADFGLSRGQEVKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIV
SLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYER
PSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEE
3D structure
PDB6mwe The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2
ChainB
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D964 A966 R968 N969 D982
Catalytic site (residue number reindexed from 1) D135 A137 R139 N140 D153
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 919 B A853 E872 L876 Y904 A905 L971 I980 A981 D982 F983 R987 Q989 A38 E43 L47 Y75 A76 L142 I151 A152 D153 F154 R158 Q160
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6mwe, PDBe:6mwe, PDBj:6mwe
PDBsum6mwe
PubMed28838996
UniProtQ02763|TIE2_HUMAN Angiopoietin-1 receptor (Gene Name=TEK)

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