Structure of PDB 6mpb Chain B

Receptor sequence
>6mpbB (length=446) Species: 9606 (Homo sapiens) [Search protein sequence]
DQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFP
GELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLA
SALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIF
PSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFG
VALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEM
EDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVT
PLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAAL
FQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAII
LEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDR
3D structure
PDB6mpb Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.
ChainB
Resolution3.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLN B S352 S353 G430 I431 G435 D464 T468 S310 S311 G388 I389 G393 D422 T426
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015186 L-glutamine transmembrane transporter activity
GO:0015194 L-serine transmembrane transporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
GO:0022834 ligand-gated channel activity
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0006868 glutamine transport
GO:0010585 glutamine secretion
GO:0015804 neutral amino acid transport
GO:0015825 L-serine transport
GO:0030218 erythrocyte differentiation
GO:0046718 symbiont entry into host cell
GO:0070207 protein homotrimerization
GO:0140009 L-aspartate import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1903803 L-glutamine import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular exosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:6mpb, PDBe:6mpb, PDBj:6mpb
PDBsum6mpb
PubMed31580259
UniProtQ15758|AAAT_HUMAN Neutral amino acid transporter B(0) (Gene Name=SLC1A5)

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