Structure of PDB 6mnl Chain B

Receptor sequence
>6mnlB (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
KDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDV
EALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKY
NPPDHEVVAMARKLQDVFEMRFAKMPDE
3D structure
PDB6mnl Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
ChainB
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B W374 V380 L385 L387 D389 Y390 C429 Y432 N433 H437 E438 V439 W42 V48 L53 L55 D57 Y58 C97 Y100 N101 H105 E106 V107
External links
PDB RCSB:6mnl, PDBe:6mnl, PDBj:6mnl
PDBsum6mnl
PubMed30518851
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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