Structure of PDB 6mm1 Chain B

Receptor sequence
>6mm1B (length=134) Species: 9606 (Homo sapiens) [Search protein sequence]
GFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRET
MRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHR
FHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGD
3D structure
PDB6mm1 The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a).
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C426 C428 H491 H535 C8 C10 H73 H117
BS02 ZN B C494 C497 H520 C523 C76 C79 H102 C105
BS03 ZN B C446 C459 C481 H484 C28 C41 C63 H66
BS04 ZN B C509 H517 C533 C536 C91 H99 C115 C118
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0008270 zinc ion binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6mm1, PDBe:6mm1, PDBj:6mm1
PDBsum6mm1
PubMed34278292
UniProtQ96KQ7|EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (Gene Name=EHMT2)

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