Structure of PDB 6mlc Chain B

Receptor sequence
>6mlcB (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
SVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCYRNYREEDLILQC
RQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRP
3D structure
PDB6mlc Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1057 C1060 C4 C7
BS02 ZN B C1069 C1078 C1081 C16 C25 C28
BS03 ZN B C1087 C1090 H1111 C1114 C34 C37 H58 C61
BS04 ZN B C1103 C1106 C1133 C1136 C50 C53 C80 C83
External links
PDB RCSB:6mlc, PDBe:6mlc, PDBj:6mlc
PDBsum6mlc
PubMed30604749
UniProtQ8NEZ4|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Gene Name=KMT2C)

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