Structure of PDB 6ml1 Chain B

Receptor sequence
>6ml1B (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
NEQPGLCGLSNLGFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMR
GEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFCQELLAFLLDGL
HEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLF
KSTLVCPECAKISVTFDPFCYLTLPLPMPKKPFVKLKDCIELFTTKEKLG
AEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLV
DFPINDLDMSGCRYNLIAVSNHYGGHYTAFAKNKDDGKWYYFDDSSVSTA
SEDQIVSKAAYVLFYQRQSSG
3D structure
PDB6ml1 Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D858 Q933 D256 Q318
BS02 CA B E450 E814 E158 E212
BS03 ZN B C448 C451 C809 C812 C156 C159 C207 C210
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6ml1, PDBe:6ml1, PDBj:6ml1
PDBsum6ml1
PubMed30713027
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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