Structure of PDB 6mdn Chain B

Receptor sequence
>6mdnB (length=707) Species: 10029 (Cricetulus griseus) [Search protein sequence]
MAGRSMQAARCPTDELSLSNCAVVSEKDYQSGQHVIVRTSPNHKYIFTLR
THPSVVPGSVAFSLPQRKWAGLSIGQEIEVALYSFDKAKQCIGTMTIEID
FLQKKNIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNDKLFGLLVK
DIEAMRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTQSIINPDWNFEK
MGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKT
LLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLG
ANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNI
LVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGH
QLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIIASVTRGDFL
ASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNS
DRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAK
CQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLK
KAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALE
LLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLA
LLREEGA
3D structure
PDB6mdn Structural principles of SNARE complex recognition by the AAA+ protein NSF.
ChainB
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.6: vesicle-fusing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B G221 P262 G265 K266 T267 L268 I406 H410 G438 E442 G204 P245 G248 K249 T250 L251 I389 H393 G421 E425
BS02 ATP B N505 G506 I507 I508 P545 G548 K549 T550 A551 K708 N474 G475 I476 I477 P514 G517 K518 T519 A520 K677
BS03 ATP B D359 R385 R388 D342 R368 R371
Gene Ontology
Molecular Function
GO:0000149 SNARE binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017075 syntaxin-1 binding
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030165 PDZ domain binding
GO:0035255 ionotropic glutamate receptor binding
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0140545 ATP-dependent protein disaggregase activity
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0006813 potassium ion transport
GO:0006886 intracellular protein transport
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0035494 SNARE complex disassembly
GO:0043001 Golgi to plasma membrane protein transport
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030496 midbody

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mdn, PDBe:6mdn, PDBj:6mdn
PDBsum6mdn
PubMed30198481
UniProtP18708|NSF_CRIGR Vesicle-fusing ATPase (Gene Name=NSF)

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