Structure of PDB 6mck Chain B

Receptor sequence
>6mckB (length=509) Species: 9606 (Homo sapiens) [Search protein sequence]
RKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVA
NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAI
APKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRR
FGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGA
DLAALCSEAALQAIRVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGG
LEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAI
ANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDS
IAKARAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLD
QLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEI
CQRACKLAIRESIESEIRRERERQTEIRRDHFEEAMRFARRSVSDNDIRK
YEMFAQTLQ
3D structure
PDB6mck Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083.
ChainB
Resolution3.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.6: vesicle-fusing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JDP B D478 I479 C522 G523 L526 I656 A659 N660 G684 A685 T688 D247 I248 C291 G292 L295 I416 A419 N420 G444 A445 T448 PDBbind-CN: -logKd/Ki=7.92,IC50=0.012uM
BindingDB: IC50=1030nM,Ki=26nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6mck, PDBe:6mck, PDBj:6mck
PDBsum6mck
PubMed30591537
UniProtP55072|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)

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