Structure of PDB 6m8q Chain B

Receptor sequence
>6m8qB (length=453) Species: 9606 (Homo sapiens) [Search protein sequence]
EESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYI
DLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWL
LSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHA
GHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIEST
YGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEY
WQNHPELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFK
HISNLKSMDHFDDIGPSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAG
YCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFI
RALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTL
NFR
3D structure
PDB6m8q CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
ChainB
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D75 H76 D179 H418 D69 H70 D173 H412
BS02 ZN B H71 H73 H158 D179 H65 H67 H152 D173
BS03 JBG B P45 L74 Y110 V240 F241 P329 G330 M331 G356 P39 L68 Y104 V234 F235 P323 G324 M325 G350
External links
PDB RCSB:6m8q, PDBe:6m8q, PDBj:6m8q
PDBsum6m8q
PubMed31819276
UniProtQ9UKF6|CPSF3_HUMAN Cleavage and polyadenylation specificity factor subunit 3 (Gene Name=CPSF3)

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