Structure of PDB 6m7x Chain B

Receptor sequence
>6m7xB (length=461) Species: 9606 (Homo sapiens) [Search protein sequence]
TVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL
GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLN
GPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGS
LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKS
TVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFYTS
IVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQ
ALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASS
DLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRRNFYHV
PFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRP
SMFPLLTFRAI
3D structure
PDB6m7x Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.
ChainB
Resolution2.095 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.15.4: steroid 11beta-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JD7 B F130 F231 G314 F381 F487 F97 F198 G276 F343 F446 MOAD: Kd=9nM
BindingDB: IC50=40nM
BS02 HEM B R110 V129 F130 W137 R141 L311 G314 R384 P442 F443 R448 C450 G452 R77 V96 F97 W104 R108 L273 G276 R346 P401 F402 R407 C409 G411
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004507 steroid 11-beta-monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0047783 corticosterone 18-monooxygenase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006694 steroid biosynthetic process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0006955 immune response
GO:0008203 cholesterol metabolic process
GO:0008217 regulation of blood pressure
GO:0016125 sterol metabolic process
GO:0032342 aldosterone biosynthetic process
GO:0032870 cellular response to hormone stimulus
GO:0034650 cortisol metabolic process
GO:0034651 cortisol biosynthetic process
GO:0035865 cellular response to potassium ion
GO:0042593 glucose homeostasis
GO:0071375 cellular response to peptide hormone stimulus
GO:1901615 organic hydroxy compound metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m7x, PDBe:6m7x, PDBj:6m7x
PDBsum6m7x
PubMed30425102
UniProtP15538|C11B1_HUMAN Cytochrome P450 11B1, mitochondrial (Gene Name=CYP11B1)

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