Structure of PDB 6m4u Chain B

Receptor sequence
>6m4uB (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
ILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSF
NQAYGRDLMEAQEWCRKYMKSGNVKDLLQAWDLYYHVFRRISK
3D structure
PDB6m4u Rational design and implementation of a chemically inducible heterotrimerization system.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAP B L2031 E2032 S2035 F2039 Y2105 F2108 L11 E12 S15 F19 Y85 F88 BindingDB: IC50=>10000nM,Kd=0.600000nM
BS02 ZN B H2028 E2032 H8 E12
BS03 ZN B D2077 H2106 D57 H86
Gene Ontology
Molecular Function
GO:0044877 protein-containing complex binding

View graph for
Molecular Function
External links
PDB RCSB:6m4u, PDBe:6m4u, PDBj:6m4u
PDBsum6m4u
PubMed32747768
UniProtP42345|MTOR_HUMAN Serine/threonine-protein kinase mTOR (Gene Name=MTOR)

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