Structure of PDB 6m4p Chain B

Receptor sequence
>6m4pB (length=375) Species: 68270 (Streptomyces spectabilis) [Search protein sequence]
PTGLPTARAAGCPFDPPPGLAALRDRAPLTRMEFPNGHVGWLATGHAVVR
AVLADPRFSHRNDRRHWPLADIGFPPLPGDMLHIDPPDHTRYRKLLAGKF
TMRRMRRLTGSAQEIVAGKLDAMERHGGPLDLLEFFARPVPTLMVCALLG
VPLQDRATFHPYVEMTYADMQEYFRKLVAAKRAAPADDLLSDLTTSDLTE
DELVGLCAVMMHAGVDSTSNMLALGTWALLERPDQLAALRERPDLADRAV
EELMRYMSVVHTGSRAALEDVELAGEVVRAGESVAFSVQAANRDPARFAD
PDTLDIRRGAVGHLGFGYGVHQCLGMQLARVEMRVAFPALFARFPALRLA
VPAGDVPMRDDLVIPYGVHRLPVTW
3D structure
PDB6m4p Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D242 S243 C349 L350 G351
Catalytic site (residue number reindexed from 1) D216 S217 C323 L324 G325
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B M90 L91 H98 R102 G240 S243 M280 V286 R291 G341 F342 H347 C349 L350 A355 M81 L82 H89 R93 G214 S217 M254 V260 R265 G315 F316 H321 C323 L324 A329
BS02 F4O B N69 R72 W74 D89 L91 H92 H238 A239 D242 V389 I390 N62 R65 W67 D80 L82 H83 H212 A213 D216 V363 I364
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6m4p, PDBe:6m4p, PDBj:6m4p
PDBsum6m4p
PubMed32908132
UniProtA0A286SBY7

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