Structure of PDB 6m1j Chain B

Receptor sequence
>6m1jB (length=187) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
GLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGYCSEISITIH
TDESITVRDNGRGIPVDIHKEEGVSAAEVIMTVLGVGVSVVNALSHELRL
TIRRHNKVWEQVYHHGVPQFPLREVGETDGSGTEVHFKPSPETFSNIHFS
WDILAKRIRELSFLNSGVGILLRDERTGKEELFKYEG
3D structure
PDB6m1j Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV.
ChainB
Resolution1.701 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EZ6 B F197 Y219 G221 F163 Y185 G187 MOAD: Ki=2nM
BS02 EZ6 B N48 S49 E52 V73 D75 R78 I80 P81 I96 T167 N32 S33 E36 V57 D59 R62 I64 P65 I80 T133 MOAD: Ki=2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6m1j, PDBe:6m1j, PDBj:6m1j
PDBsum6m1j
PubMed32787097
UniProtQ9I7C2|GYRB_PSEAE DNA gyrase subunit B (Gene Name=gyrB)

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