Structure of PDB 6lxi Chain B

Receptor sequence
>6lxiB (length=387) Species: 88776 (Influenza A virus (A/Brevig Mission/1/1918(H1N1))) [Search protein sequence]
VILTGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIREPFISCSHLECRTF
FLTQGALLNDKHSNGTVKDRSPYRTLMSCPVGEAPSPYNSRFESVAWSAS
ACHDGMGWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECA
CVNGSCFTIMTDGPSNGQASYKILKIEKGKVTKSIELNAPNYHYEECSCY
PDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGYICSGVFGDNPRPNDGT
GSCGPVSSNGANGIKGFSFRYDNGVWIGRTKSTSSRSGFEMIWDPNGWTE
TDSSFSVRQDIVAITDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGQPK
ENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFSIDK
3D structure
PDB6lxi Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC B N146 G147 K150 Q430 N64 G65 K68 Q348
BS02 CA B D294 G298 D324 G342 N344 D212 G216 D242 G260 N262
BS03 CA B D376 N378 D384 S386 D294 N296 D302 S304
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0033644 host cell membrane
GO:0044423 virion component
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lxi, PDBe:6lxi, PDBj:6lxi
PDBsum6lxi
PubMed33024040
UniProtQ9IGQ6|NRAM_I18A0 Neuraminidase (Gene Name=NA)

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