Structure of PDB 6lrl Chain B

Receptor sequence
>6lrlB (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDAAGMVKGVVDHLLLRLKCDSAFRGVGLLNGSY
KISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFSQFLEGEILSASKML
SKFRKIIKEEINDDTDVTLLIKISVDITLALESKSSWPASTQEGLRIQNW
LSAKVRKQLRLKPFYLVPKTWRLSFSHIEKEILNNHGKSKTCCENKEEKC
CRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQ
WDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFL
TKQIEYERNNEFPVFD
3D structure
PDB6lrl In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
ChainB
Resolution2.655 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H390 C396 C397 C404 H186 C192 C193 C200
BS02 ER9 B R376 S434 Y436 H437 N482 R172 S230 Y232 H233 N278
External links
PDB RCSB:6lrl, PDBe:6lrl, PDBj:6lrl
PDBsum6lrl
PubMed32459092
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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