Structure of PDB 6lq1 Chain B

Receptor sequence

>6lq1B (length=607) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]

SHYKSNVRDQVFNLFEVFGVDKVLGADKFSDLDADTAREMLTEIARLAEG
PIAESFVEGDRNPPVFDPETHTVTLPEGFKKSMRALFDGGWDKVGLAEHL
GGIPMPRALQWALIEHILGANPAAYMYAMGPGMSEIFYNNGTDEQKKWAT
IAAERGWGATMVLTEPDAGSDVGAGRTKAVQQPDGTWHIEGVKRFITSAD
SDDLFENIMHLVLARPEGAGPGTKGLSLFFVPKFHFDHETGEIGERNGVF
VTNVEHKMGLKVSATCELSLGQHGIPAVGWLVGEVHNGIAQMFDVIEQAR
MMVGTKAIATLSTGYLNALEYAKERVQGADMTQMTDKTAPRVTITHHPDV
RRSLMTQKAYAEGLRAIYLYTATFQDAEVAQAVHGVDGDLAARVNDLLLP
IVKGFGSETAYAKLTESLQTLGGSGFLQDYPIEQYIRDSKIDSLYAGTTA
IQAQDFFFRKIIRDKGQALAYVAGEIEQFIKNNGRLKTERELLATALADV
QGMAASLTGYLMAAQEDAASIYKVGLGSVRFLMAVGDLLSGWLLARQAAV
AIEKLDAGATGADKSFYEGKIAAASFFAKNMLPLLTSTRQIIENLDNDVM
ELDEAAF

3D structure

PDB

6lq1 Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.3.8.1: short-chain acyl-CoA dehydrogenase.
1.3.8.7: medium-chain acyl-CoA dehydrogenase.
1.3.8.8: long-chain-acyl-CoA dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	B	R326 Q328 H348 Q420 G423 G424	R325 Q327 H347 Q419 G422 G423
BS02	FAD	B	L164 T165 G170 S171 F196 T198 T266 I442 Y446 T449	L163 T164 G169 S170 F195 T197 T265 I441 Y445 T448
BS03	OCA	B	M130 M134 Y446 A447	M129 M133 Y445 A446
BS04	COA	B	M162 L164 S171 V173 T224 I290 F294 R301 A447 G448 I452 D456 R460 K461	M161 L163 S170 V172 T223 I289 F293 R300 A446 G447 I451 D455 R459 K460

Gene Ontology

	Molecular Function
GO:0004466	long-chain fatty acyl-CoA dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937	short-chain fatty acyl-CoA dehydrogenase activity
GO:0070991	medium-chain fatty acyl-CoA dehydrogenase activity

	Biological Process
GO:0006631	fatty acid metabolic process

	Cellular Component
GO:0005886	plasma membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6lq1, PDBe:6lq1, PDBj:6lq1
PDBsum	6lq1
PubMed	32601219
UniProt	Q3L887\|FADE5_MYCS2 Broad-specificity linear acyl-CoA dehydrogenase FadE5 (Gene Name=fadE5)

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