Structure of PDB 6l6r Chain B

Receptor sequence
>6l6rB (length=610) Species: 9606 (Homo sapiens) [Search protein sequence]
DPLLLYANRRDLRLVDATNENATIVVGGLEDAAAVDFVFSHGLIYWSDVS
EEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEV
SNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGS
SRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVK
GSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDI
HAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGK
TCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVE
GYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTD
TGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKI
ERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDG
TGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQ
LPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELI
SDMKTCIVPH
3D structure
PDB6l6r Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains.
ChainB
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S114 N117 D138 Q139 S93 N96 D117 Q118
BS02 MG B I143 H272 I122 H251
External links
PDB RCSB:6l6r, PDBe:6l6r, PDBj:6l6r
PDBsum6l6r
PubMed33097721
UniProtO75581|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

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